Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats
Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated.To ensure the accuracy of the results, a rapid and sensitive UPLC−MS/MS method PUSH DAGGER was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin acid (SVA).This method was applied for st